Scientists create opioid with reduced overdose potential

Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose. In a study appearing in ACS Central Science, researchers have identified a strategy to design safer opioids. They showed that an experimental opioid, which binds to an unconventional … Read more

Photocatalytic quadruple electron transfer enables light-driven ester reduction

The sweet smell of strawberries and other fruits is thanks to a chemical compound called ester, which is also found in many fats and polyesters. The ubiquitous compound can be broken down to produce desirable alcohols and other chemicals for use across industries, including pharmaceuticals and cosmetics, but the process can be costly, both financially … Read more

Vitamin B6 breakdown inhibitor shows promise for vrain disorders

A low vitamin B6 level has negative effects on brain performance. A research team from Würzburg University Medicine has now found a way to delay the degradation of the vitamin. Vitamin B6 is important for brain metabolism. Accordingly, in various mental illnesses, a low vitamin B6 level is associated with impaired memory and learning abilities, … Read more

Revolutionary carbon fiber electrocatalysts pave the way for affordable green hydrogen production

A groundbreaking technology has been developed to address the limitations of current catalyst electrodes, facilitating the large-scale production of green hydrogen at a relatively low cost. This significant advancement was published in the Journal of the American Chemical Society. The innovative project was led by Professor Han Gi Chae from the Department of Materials Science … Read more

Halogen bonds orchestrate ultrafast dynamics in multifunctional crystals

Researchers have uncovered how the halogen bond can be exploited to direct sequential dynamics in multi-functional crystals, offering crucial insights for developing ultrafast-response times for multilevel optical storage. Halogen bonds are intermolecular interactions that arise from the attraction between a halogen atom (group 17 elements in the periodic table) and another atom with lone pairs, … Read more

Innovative dual-mode films offer enhanced security against counterfeiting

As concerns about data theft and counterfeiting grow, so does the need for sophisticated security technologies to verify the authenticity of important documents like currency and passports. Traditional methods, such as hologram seals, are continually challenged by evolving criminal techniques. In response, researchers are developing advanced solutions to stay ahead of these threats. A team … Read more

Discovery of PrMgAl11O19 single crystals advances spin liquid research

A spin liquid is a fascinating state of matter that occurs in certain magnetic materials at very low temperatures. Unlike conventional magnetic states where electron spins align in a regular pattern, spin liquids exhibit a disordered state due to the peculiarities of quantum mechanics. This state of matter does not resemble everyday liquids but is … Read more

Single-atom iron catalysts for water purification

The rapid increase in global industrialization in the past centuries has resulted in the disposal of excessive toxic pollutants into the environment, seriously threatening the aquatic ecosystem and human health. Peroxymonosulfate-based advanced oxidation processes (PMS-AOPs) are appealing techniques to treat these toxic pollutants. Leveraging diverse reactive oxygen species (ROS), AOPs are sought to oxidize or … Read more

PhaseLift-based photoemission orbital tomography simplifies 3D MO visualization in materials

Discoveries and progress in materials science often lay the foundation for technological breakthroughs that reshape many industrial and commercial fields, including medicine, consumer electronics, and energy generation. The development of experimental techniques is crucial in exploring new materials, paving the way for groundbreaking discoveries. These techniques allow scientists to delve into a material’s chemical and … Read more

First-ever measurement of promethium’s chemical bond fills gap in rare earth knowledge

Scientists have recently uncovered new properties of promethium, a rare earth element first discovered 80 years ago at Clinton Laboratories, now known as the Department of Energy’s Oak Ridge National Laboratory (ORNL). This breakthrough opens a new pathway for exploring elements that are critical in modern technology, including applications in medicine and space travel. Promethium, … Read more

Review examines non-classical crystallization pathways in soft and organic materials

Soft and organic crystals are a diverse group of materials with connections to biological, environmental, and industrial processes with a wide range of applications, from pharmaceuticals to flexible electronics. Understanding the details of their crystallization pathways is essential to developing the ability to controllably synthesize new materials and structures with targeted properties. A new review … Read more

Researchers develop eco-friendly photocatalyst for sustainable chemical manufacturing

In recent years, global environmental concerns have prompted a significant shift toward eco-friendly manufacturing processes in organic synthetic chemistry. One such advancement is the use of photoredox catalytic reactions, which leverage light to drive redox reactions via a photoredox catalyst. This method reduces the reliance on harsh and toxic reagents, utilizing visible light as a … Read more

Researchers discover novel antiaromatic π-stacking system for conductive liquid crystals

In organic chemistry, π-stacking systems are supramolecular structures that arise due to the dispersion force, a type of intermolecular noncovalent interaction. They are a common occurrence in nature. The stabilized structure of DNA is a very prominent example of a π-stacking system, and so are the arrangement of amino acids in certain proteins. Interestingly, π-stacking … Read more

Chemists develop method for site-selective difluoromethylation of pyridines

In a significant advancement for drug research and chemical synthesis, a team of chemists at the University of Münster has devised a new method to precisely integrate the biologically significant difluoromethyl group into pyridines at specific sites. The difluoromethyl group, composed of carbon, two fluorine atoms, and a hydrogen atom, is crucial for determining the … Read more

Researchers discover unconventional catalyst enhancement via anion implantation

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory has found an unconventional way to improve catalysts made of more than one material. The solution demonstrates a path to designing catalysts with greater activity, selectivity and stability. A catalyst normally uses a support to stabilize nanometer-sized metal particles that speed … Read more

Study suggests rethinking time steps in water simulations for improved accuracy

Computational scientists at the Department of Energy’s Oak Ridge National Laboratory have published a study in the Journal of Chemical Theory and Computation that questions a long-accepted factor in simulating the molecular dynamics of water: the 2-femtosecond (one quadrillionth of a second) time step. The femtosecond is a timescale used by scientists to measure the … Read more

Researchers develop eco-friendly high refractive index polymers for optoelectronic devices

High refractive index polymers (HRIPs) are essential for manufacturing modern optoelectronic devices, including displays and light sensors. However, high-performance HRIPs are expensive and environmentally unfriendly. Recently, a research team from Waseda University developed a new family of HRIPs called poly(thiourea)s. Thanks to unique intermolecular interactions, these compounds can be easily processed into low-cost transparent HRIPs … Read more

Study solves lag mystery in organic electrochemical transistors (OECTs)

Researchers who want to bridge the divide between biology and technology spend a lot of time thinking about translating between the two different “languages” of those realms. “Our digital technology operates through a series of electronic on-off switches that control the flow of current and voltage,” said Rajiv Giridharagopal, a research scientist at the University … Read more

Researchers create synthetic droplets mimicking chemotaxis in early life

Our bodies are made up of trillions of different cells, each fulfilling their own unique function to keep us alive. How do cells move around inside these extremely complicated systems? How do they know where to go? And how did they get so complicated to begin with? Simple yet profound questions like these are at … Read more

Chemist discovers catalyst’s assisting role in benzotriazole conversion

In most industrial chemical reactions, catalysts combine with the starting materials and accompany them through intermediate stages to the product. In chemistry, this pathway is known as the reaction mechanism, and it is a kind of black box: nobody knows what is happening at the molecular level at first. If the reaction result in the … Read more