Novel mechanism for kidney regeneration discovered

A recent study led by USC Stem Cell scientist Janos Peti-Peterdi reveals that a loss of salt and body fluid can stimulate kidney regeneration and repair in mice. This groundbreaking research, published in the Journal of Clinical Investigation, uncovers an innate regenerative response driven by a small population of kidney cells known as the macula … Read more

Study identifies crucial molecule for healthy kidney development in babies

Some infants are born with too few nephrons, the filtering units in kidneys that help the body remove waste and excess fluid. Whether due to low birth weight, maternal diabetes, inadequate nutrition or genetic mutations, babies born with improper kidney development are more likely to face a lifetime of challenges such as high blood pressure … Read more

Deletion of kidney glucagon receptors induces chronic kidney disease-like symptoms in mice

Glucagon, recognized primarily for its role in stimulating blood sugar production in the liver, has emerged as a pivotal player in maintaining kidney health, according to recent research from UT Southwestern Medical Center. The study, published in Cell Metabolism, illuminates glucagon’s broader physiological functions and unveils its significance in combating chronic kidney disease (CKD), a … Read more

Recalibrated polygenic risk scores improve disease risk pediction in diverse populations

To prevent an emerging genomic technology from contributing to health disparities, a scientific team has devised new ways to improve a genetic testing method called a polygenic risk score. Since polygenic risk scores have not been effective for all populations, the researchers recalibrated these genetic tests using ancestrally diverse genomic data. As reported in Nature … Read more