Research led by Weill Cornell Medicine has uncovered pivotal evidence suggesting that most colorectal cancers originate from the loss of intestinal stem cells prior to the onset of cancer-causing genetic mutations. This breakthrough, detailed in a study published on May 29 in Developmental Cell, challenges the longstanding theory of colorectal tumor initiation and opens new … Read more
Animal development, also known as embryonic development, encompasses the complex processes through which a single fertilized egg cell transforms into a multicellular organism with distinct tissues, organs, and body structures. This intricate journey involves cellular differentiation, tissue organization, morphogenetic movements, and regulatory mechanisms that orchestrate the formation of body axes, germ layers, organ systems, and … Read more
Neuroplasticity, also known as brain plasticity or neural plasticity, is a fundamental property of the brain that refers to its ability to change and adapt throughout life in response to experiences, learning, environmental stimuli, injury, and disease. This remarkable capacity for structural and functional reorganization enables the brain to modify neural pathways, establish new connections, … Read more
Gene editing technologies have revolutionized the field of molecular biology and genetics by providing powerful tools to precisely modify DNA sequences, study gene functions, correct genetic mutations, and engineer biological systems. Among the most widely used and transformative gene editing technologies is CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and its associated protein, Cas (CRISPR-associated … Read more
Developmental biology is a fascinating field that explores the processes governing the growth, differentiation, and organization of cells into complex multicellular organisms. From the moment of fertilization, when a sperm cell fuses with an egg cell, to the formation of fully functional organs and tissues, developmental biology seeks to unravel the intricate molecular, cellular, and … Read more
Nonsense-mediated RNA decay, or NMD, is an evolutionarily conserved molecular mechanism in which potentially defective messenger RNAs, or mRNAs (genetic material that instructs the body on how to make proteins), are degraded. Disruption of the NMD pathway can lead to neurological disorders, immune diseases, cancers, and other pathologies. Mutations in human NMD regulators are seen … Read more
Airway hillocks are mysterious, flat-topped structures that were only recently identified within regular lung tissue, and their role in airway biology and pathology has previously been unknown. A research team from Tufts University School of Medicine and Massachusetts General Hospital is now reporting evidence that hillocks and their stem cells are physiologically distinct from other … Read more
Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells (HSCs) are remarkably long-lived. HSCs are blood-forming cells—they give rise to rapidly dividing progenitor cells, which in turn generate hundreds of billions of cells to fulfill the daily demand of oxygen-delivering red blood cells, disease-fighting white blood cells and clot-forming platelets. … Read more
Researchers have discovered the mechanism which allows adult brain stem cells to express genes that maintain their identity and those for neuronal differentiation without conflicts in cellular activity. Furthermore, this mechanism enables stem cells to be prepared to respond to differentiation signals readily. All cells in an organism have the same genes, but the difference … Read more
If mice ever wonder what it’s like to experience the world as a rat, some are now able to live that dream, at least when it comes to the sense of smell. Researchers led by Columbia University’s Kristin Baldwin have created mice with hybrid brains—part mouse, part rat—that sense the odors of the world with … Read more
By discovering how a type of smooth muscle—which is essential for mechanical aspects of absorbing fats from food—forms in the gut, Cornell scientists have opened doors to making artificial muscle, repairing muscle following gut surgeries, and treating inflammatory bowel disease and obesity. The findings, published in a study in Developmental Cell, reveal that intestinal smooth muscle originates in … Read more
Compared to adults, newborns are highly susceptible to infections and these infections can cause serious health complications and even death. One factor known to affect a newborn’s response to infection is a condition called neonatal neutropenia, in which the infant fails to make enough neutrophils, the immune system’s first responders. What underlies this immune deficiency, … Read more
Some infants are born with too few nephrons, the filtering units in kidneys that help the body remove waste and excess fluid. Whether due to low birth weight, maternal diabetes, inadequate nutrition or genetic mutations, babies born with improper kidney development are more likely to face a lifetime of challenges such as high blood pressure … Read more
A mutated protein expressed in lysosomes may contribute to Parkinson’s disease, according to a new Northwestern Medicine study published in the Journal of Cell Biology. Parkinson’s disease is the second-most common neurodegenerative disorder in the U.S., after Alzheimer’s disease. The National Institutes of Neurological Disorders and Stroke estimates that as many as one million Americans … Read more
When a child falls off her bike and scrapes her knee, skin stem cells rush to the rescue, growing new epidermis to cover the wound. But only some of the stem cells that will ultimately patch her up are normally dedicated to replenishing the epidermis that protects her body. Others are former hair follicle stem … Read more
Queensland researchers have become the first in Australia to use human stem cells to generate fully functioning skin tissue in a laboratory, a significant step toward better treatments for severe burns and wounds. The skin tissue, produced by The University of Queensland’s Frazer Institute and Metro North Health’s Herston Biofabrication Institute, can develop hair follicles … Read more
Thanks to advancements in the development of patented synthetic human-like hearts first created at Michigan State, researchers can study human heart development and congenital heart disease on highly accurate models. This is facilitating the development of new therapies and pharmaceutical drugs to treat a variety of heart-related diseases just in time for the observance of … Read more
Researchers from Bochum and Dortmund have created an artificial cell environment that could promote the regeneration of nerves. Usually, injuries to the brain or spinal cord don’t heal easily due to the formation of fluid-filled cavities and scars that prevent tissue regeneration. One starting point for medical research is therefore to fill the cavities with … Read more
RNA polymerase is a key enzyme involved in the process of transcription, where genetic information encoded in DNA is transcribed into RNA molecules. This enzyme plays a crucial role in gene expression, as it catalyzes the synthesis of RNA strands complementary to a DNA template strand. Through its intricate structure and precise mechanism of action, … Read more
Scientists have combined laser 3D printing technology and an alternate soaking process to construct complex 3D structures that mimic bone microstructure. This is the first demonstration of this fabrication method, and it will lead to the development of 3D cell culture systems that can support bone grafts or create artificial bone marrow. Their research is … Read more