Proteins

Study discovers promising immune response for early ovarian cancer diagnosis

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Researchers at Children’s Hospital of Philadelphia (CHOP) announced the discovery of a novel immune-based biomarker that could pave the way for potential lifesaving early detection of high-grade ovarian cancer (HGOC). The findings were published today in the journal Cell Reports Medicine. High-grade ovarian cancer (HGOC) is the fifth-leading cause of cancer-related death among women. More than 90% of … Read more

New nanomedicine therapy combines drug delivery and enhanced immunity for lung cancer

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Researchers at Brigham and Women’s Hospital have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system’s ability to fight cancer. The team showed promising results for the new therapy in cancer cells in the lab and in mouse lung tumor models, with potential applications for improving … Read more

Researchers discover mechanism disrupting cell signaling pathways

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A group of researchers at University of California San Diego has identified the cause of a “short-circuit” in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases. The recent study, published in the journal Science Signaling, explores the biochemical mechanism that can interrupt the cellular communication chain—a … Read more

Biomolecular analysis of fragmented bones sheds light on North American megafaunal extinction

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50,000 years ago, North America was ruled by megafauna. Lumbering mammoths roamed the tundra, while forests were home to towering mastodons, fierce saber-toothed tigers and enormous wolves. Bison and extraordinarily tall camels moved in herds across the continent, while giant beavers plied its lakes and ponds. Immense ground sloths weighing over 1,000 kg were found … Read more

Early memory complaints may signal preclinical Alzheimer’s disease, new study finds

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A groundbreaking study underscores the importance of addressing concerns about persistent memory loss with a healthcare provider. Conducted by researchers from Mass General Brigham, the study reveals that reports of cognitive decline by patients and their close family members or study partners may indicate early changes in the brain associated with Alzheimer’s disease. This discovery … Read more

New research reveals loss of intestinal stem cells as early trigger for colorectal cancer

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Research led by Weill Cornell Medicine has uncovered pivotal evidence suggesting that most colorectal cancers originate from the loss of intestinal stem cells prior to the onset of cancer-causing genetic mutations. This breakthrough, detailed in a study published on May 29 in Developmental Cell, challenges the longstanding theory of colorectal tumor initiation and opens new … Read more

Study reveals surprising dynamics of brain blood flow

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For the first time, researchers have successfully visualized the intricate network of blood vessels spanning the cortex of awake mice. Their groundbreaking observations revealed that these blood vessels rhythmically expand and contract, creating “waves” that wash across the brain’s surface. This discovery, published in the journal Neuron, significantly enhances our understanding of cerebral blood flow, … Read more

Dynamic disorder unravels the mystery of slowdown in supercooled water

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A scientist at the Institute for Molecular Science has published a study that provides insight into the puzzling phenomenon of dynamic slowdown in supercooled water, an essential step toward understanding the glass transition in liquids. The study, “Unraveling the dynamic slowdown in supercooled water: The role of dynamic disorder in jump motions,” explores the microscopic … Read more

How brain activation affects behavior

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Our brains are made of tens of billions of nerve cells called neurons. These cells communicate with each other through biomolecules called neurotransmitters. Serotonin, a type of neurotransmitter, is produced by serotonin neurons in our brains and influences many of our behavioral and cognitive functions such as memory, sleep, and mood. Using mice, scientists at … Read more

Study shows breakthrough infections enhance immune response to COVID-19

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New research from scientists at La Jolla Institute for Immunology (LJI) suggests people who received COVID-19 vaccines and then experienced “breakthrough” infections are especially well armed against future SARS-CoV-2 infections. By analyzing blood samples from study volunteers, the LJI researchers discovered that people who experienced symptomatic breakthrough infections develop T cells that are better at … Read more

Researchers discover novel antiaromatic π-stacking system for conductive liquid crystals

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In organic chemistry, π-stacking systems are supramolecular structures that arise due to the dispersion force, a type of intermolecular noncovalent interaction. They are a common occurrence in nature. The stabilized structure of DNA is a very prominent example of a π-stacking system, and so are the arrangement of amino acids in certain proteins. Interestingly, π-stacking … Read more

Engineers develop world-record microwave squeezer for dark matter detection

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UNSW quantum engineers have developed a new amplifier that could help other scientists search for elusive dark matter particles. Imagine throwing a ball. You’d expect science to be able to work out its exact speed and location at any given moment, right? Well, the theory of quantum mechanics says you can’t actually know both with … Read more

Scientists unravel how plants decide to grow or make oil

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Proteins are molecular machines, with flexible pieces and moving parts. Understanding how these parts move helps scientists unravel the function a protein plays in living things—and potentially how to change its effects. Biochemists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory and colleagues at DOE’s Pacific Northwest National Laboratory (PNNL) have published a … Read more

Researchers discover new cell death pathway in response to DNA damage

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Chemotherapy kills cancer cells. But the way these cells die appears to be different than previously understood. Researchers from the Netherlands Cancer Institute, led by Thijn Brummelkamp, have uncovered a completely new way in which cancer cells die: due to the Schlafen11 gene. “This is a very unexpected finding. Cancer patients have been treated with … Read more

Microbial Genetics: Genetic Mechanisms in Bacteria and Archaea

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Microbial genetics is a specialized field within genetics that focuses on the study of genetic mechanisms in bacteria and archaea, collectively referred to as microorganisms or microbes. These single-celled organisms play crucial roles in various ecosystems, contributing to nutrient cycling, biogeochemical processes, symbiotic relationships, and human health. Microbial genetics explores the diversity, evolution, regulation, and … Read more

Systems Biology: Integrating Biological Processes into Complex Systems

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Systems biology is an interdisciplinary field that seeks to understand biological systems as integrated networks of components, processes, and interactions, rather than isolated parts. It combines principles from biology, mathematics, computer science, engineering, and other disciplines to analyze complex biological phenomena at multiple scales, from molecular and cellular levels to tissues, organs, organisms, populations, and … Read more

Neuroplasticity: Brain’s Ability to Change and Adapt

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Neuroplasticity, also known as brain plasticity or neural plasticity, is a fundamental property of the brain that refers to its ability to change and adapt throughout life in response to experiences, learning, environmental stimuli, injury, and disease. This remarkable capacity for structural and functional reorganization enables the brain to modify neural pathways, establish new connections, … Read more

Comparative Anatomy: Comparing Anatomy Across Species

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Comparative anatomy is a branch of biology that involves the study of anatomical structures and systems across different species to understand evolutionary relationships, adaptations, functional morphology, and biological diversity. By comparing the anatomy of organisms from various taxonomic groups, researchers can gain insights into evolutionary patterns, developmental processes, physiological functions, and ecological adaptations that have … Read more

Plant Genetics: Breeding and Genetic Modification

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Plant genetics encompasses the study of genes, heredity, and genetic variation in plants, including their breeding, genetic modification, inheritance patterns, molecular mechanisms, and applications in agriculture, horticulture, forestry, and biotechnology. Understanding plant genetics is essential for improving crop traits, developing new crop varieties, enhancing agricultural productivity, ensuring food security, and addressing global challenges such as … Read more

Gene Editing Technologies: CRISPR and Beyond

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Gene editing technologies have revolutionized the field of molecular biology and genetics by providing powerful tools to precisely modify DNA sequences, study gene functions, correct genetic mutations, and engineer biological systems. Among the most widely used and transformative gene editing technologies is CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and its associated protein, Cas (CRISPR-associated … Read more