Telo-seq: A high-resolution method for studying telomere dynamics in aging and disease

Within each of our cells, long strands of DNA are folded into chromosomes and capped with protective structures called telomeres. Telomeres shorten as we age, eventually becoming so diminished that our chromosomes are exposed, leading to cell death. The specifics of this shortening process, and whether certain chromosomes are more affected than others, have remained … Read more

Study discovers promising immune response for early ovarian cancer diagnosis

Researchers at Children’s Hospital of Philadelphia (CHOP) announced the discovery of a novel immune-based biomarker that could pave the way for potential lifesaving early detection of high-grade ovarian cancer (HGOC). The findings were published today in the journal Cell Reports Medicine. High-grade ovarian cancer (HGOC) is the fifth-leading cause of cancer-related death among women. More than 90% of … Read more

New nanomedicine therapy combines drug delivery and enhanced immunity for lung cancer

Researchers at Brigham and Women’s Hospital have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system’s ability to fight cancer. The team showed promising results for the new therapy in cancer cells in the lab and in mouse lung tumor models, with potential applications for improving … Read more

Study reveals potential cancer-fighting benefits of consuming small fish

A groundbreaking study has found compelling evidence linking the consumption of small fish, eaten whole, with a lower risk of all-cause and cancer mortality in Japanese women. Spearheaded by Dr. Chinatsu Kasahara, Associate Professor Takashi Tamura, and Professor Kenji Wakai at Nagoya University Graduate School of Medicine, this research underscores the potential health benefits of … Read more

Ancient Egyptian skulls offer evidence of possible cancer treatment

From ancient texts we know that—for their times—the ancient Egyptians were exceptionally skilled at medicine. For example, they could identify, describe, and treat diseases and traumatic injuries, build protheses, and put in dental fillings. Other conditions, like cancer, they couldn’t treat—but they might have tried. Examining the limits of traumatological and oncological treatments in ancient … Read more

Researchers discover mechanism disrupting cell signaling pathways

A group of researchers at University of California San Diego has identified the cause of a “short-circuit” in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases. The recent study, published in the journal Science Signaling, explores the biochemical mechanism that can interrupt the cellular communication chain—a … Read more

New research reveals loss of intestinal stem cells as early trigger for colorectal cancer

Research led by Weill Cornell Medicine has uncovered pivotal evidence suggesting that most colorectal cancers originate from the loss of intestinal stem cells prior to the onset of cancer-causing genetic mutations. This breakthrough, detailed in a study published on May 29 in Developmental Cell, challenges the longstanding theory of colorectal tumor initiation and opens new … Read more

Study links PI5P4K activity to hippo pathway regulation in cancer

Within the intricate landscape of cell membrane lipids and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have long dominated scientific research, particularly due to their roles in cancer, diabetes, and various cellular functions. However, the spotlight on PI3Ks has often overshadowed other crucial members of this lipid enzyme family, including phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks). … Read more

First-ever measurement of promethium’s chemical bond fills gap in rare earth knowledge

Scientists have recently uncovered new properties of promethium, a rare earth element first discovered 80 years ago at Clinton Laboratories, now known as the Department of Energy’s Oak Ridge National Laboratory (ORNL). This breakthrough opens a new pathway for exploring elements that are critical in modern technology, including applications in medicine and space travel. Promethium, … Read more

How viruses could become the next cancer treatment

In the global quest for effective cancer treatments, researchers are uncovering promising strategies in the most unexpected of places: the very viruses we typically strive to avoid. Pathogens such as the common cold and influenza, once seen solely as threats to our health, are now being studied for their potential to target and destroy cancer … Read more

Heatmaps reveal different trematode species favor specific body locations in amphibian hosts

Trematodes, also known as flukes, are a class of parasitic flatworms with intricate lifecycles. This makes them interesting to scientists, but they are also significant to both human health and wildlife conservation. Trematodes can cause infection in humans when people eat food the flatworms have contaminated, including raw fish, crustaceans and vegetables. Though this is … Read more

Study links UV exposure to increased energy expenditure and reduced weight gain in mice

Obesity and metabolic disorders are increasingly significant global public health issues. In a novel study, a team of dermatologists has evaluated the effect of ultraviolet (UV) exposure on appetite and weight regulation. They found that UV exposure raises norepinephrine levels, decreases leptin levels, and induces the browning of subcutaneous fat, thereby increasing energy expenditure. These … Read more

Researchers discover new cell death pathway in response to DNA damage

Chemotherapy kills cancer cells. But the way these cells die appears to be different than previously understood. Researchers from the Netherlands Cancer Institute, led by Thijn Brummelkamp, have uncovered a completely new way in which cancer cells die: due to the Schlafen11 gene. “This is a very unexpected finding. Cancer patients have been treated with … Read more

Systems Biology: Integrating Biological Processes into Complex Systems

Systems biology is an interdisciplinary field that seeks to understand biological systems as integrated networks of components, processes, and interactions, rather than isolated parts. It combines principles from biology, mathematics, computer science, engineering, and other disciplines to analyze complex biological phenomena at multiple scales, from molecular and cellular levels to tissues, organs, organisms, populations, and … Read more

Aquatic Biology: Life in Water Environments

Aquatic biology is a branch of biology that focuses on the study of life in water environments, encompassing a wide range of organisms, ecosystems, and processes that thrive in aquatic habitats. From the smallest microorganisms to the largest marine mammals, aquatic biology explores the diversity, adaptations, interactions, and ecological dynamics of aquatic life across freshwater, … Read more

Gene Editing Technologies: CRISPR and Beyond

Gene editing technologies have revolutionized the field of molecular biology and genetics by providing powerful tools to precisely modify DNA sequences, study gene functions, correct genetic mutations, and engineer biological systems. Among the most widely used and transformative gene editing technologies is CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and its associated protein, Cas (CRISPR-associated … Read more

FAK inhibitor shows promise in converting acinar cells to insulin-producing cells in diabetic mice and primate

In 2016, University of Pittsburgh researchers Dr. Farzad Esni, Ph.D., and Jing Hu, Ph.D., did an experiment in mice where they deleted one of two copies of the gene encoding an enzyme called focal adhesion kinase (FAK). They were interested in the role of FAK in pancreatic cancer, but a surprise finding took the research … Read more

Epidemiology: Study of Disease Patterns and Spread

Epidemiology is the study of the distribution and determinants of health-related states or events in populations and the application of this study to control health problems. It is a cornerstone of public health, providing insights into the patterns, causes, and impacts of diseases within populations. Epidemiologists investigate the occurrence of diseases, injuries, disabilities, and deaths, … Read more

Genomics: Mapping Genomes and Genetic Variation

Genomics is a field of biology that focuses on the study of genomes, which are the complete sets of genetic material (DNA) present in an organism. Genomics encompasses a wide range of disciplines, techniques, and methodologies aimed at mapping genomes, analyzing genetic variation, understanding gene function, and elucidating the genetic basis of traits, diseases, and … Read more

Immunotherapy: Harnessing the Immune System for Disease Treatment

Immunotherapy represents a revolutionary approach to disease treatment that harnesses the power of the immune system to combat various ailments, including cancer, autoimmune disorders, infectious diseases, and allergies. Unlike traditional treatments such as chemotherapy or surgery, which directly target the disease, immunotherapy works by stimulating or enhancing the body’s immune response to recognize and destroy … Read more