Telo-seq: A high-resolution method for studying telomere dynamics in aging and disease

Within each of our cells, long strands of DNA are folded into chromosomes and capped with protective structures called telomeres. Telomeres shorten as we age, eventually becoming so diminished that our chromosomes are exposed, leading to cell death. The specifics of this shortening process, and whether certain chromosomes are more affected than others, have remained … Read more

New study creates high-resolution map of gene expression in sorghum stem tissue

Bioenergy sorghum is an important resource for the production of biofuels and bioproducts and a critical component of a sustainable agricultural future. Researchers have been working hard to make this tall, drought-tolerant plant even more productive and resilient to harsh environmental conditions. But those efforts are hampered by a lack of knowledge about the inner … Read more

Animal Development: Embryonic Development and Morphogenesis

Animal development, also known as embryonic development, encompasses the complex processes through which a single fertilized egg cell transforms into a multicellular organism with distinct tissues, organs, and body structures. This intricate journey involves cellular differentiation, tissue organization, morphogenetic movements, and regulatory mechanisms that orchestrate the formation of body axes, germ layers, organ systems, and … Read more

Developmental Biology: Processes from Fertilization to Organism Formation

Developmental biology is a fascinating field that explores the processes governing the growth, differentiation, and organization of cells into complex multicellular organisms. From the moment of fertilization, when a sperm cell fuses with an egg cell, to the formation of fully functional organs and tissues, developmental biology seeks to unravel the intricate molecular, cellular, and … Read more

Plant Anatomy: Structure and Function of Plant Tissues

Plant anatomy is the study of plant structure at cellular and tissue levels. Plant tissues, such as meristematic, dermal, ground, and vascular tissues, each perform distinct functions crucial for plant growth, support, and survival. Meristematic tissue drives growth, while dermal tissue protects against environmental stresses. Ground tissue aids in photosynthesis and storage, while vascular tissue … Read more

Animal Physiology: Functions and Adaptations in Animals

Animal physiology is the branch of biology that focuses on understanding the biological functions and adaptations of animals, ranging from microscopic organisms to complex multicellular organisms. It encompasses a wide range of topics, including cellular processes, organ systems, homeostasis, metabolism, reproduction, behavior, and adaptations to diverse environments. By studying animal physiology, scientists gain insights into … Read more

Study links nonsense-mediated RNA decay to brain size control in mice

Nonsense-mediated RNA decay, or NMD, is an evolutionarily conserved molecular mechanism in which potentially defective messenger RNAs, or mRNAs (genetic material that instructs the body on how to make proteins), are degraded. Disruption of the NMD pathway can lead to neurological disorders, immune diseases, cancers, and other pathologies. Mutations in human NMD regulators are seen … Read more

Researchers develop hormone-free plant regeneration using developmental regulator genes

For ages now, plants have been the primary source of nutrition for animals and mankind. Additionally, plants are used for the extraction of various medicinal and therapeutic compounds. However, their indiscriminate use, along with the rising demand for food, underscores the need for novel plant breeding practices. Advances in plant biotechnology can address the problems … Read more

Study reveals protective and regenerative roles of airway hillocks in lung function

Airway hillocks are mysterious, flat-topped structures that were only recently identified within regular lung tissue, and their role in airway biology and pathology has previously been unknown. A research team from Tufts University School of Medicine and Massachusetts General Hospital is now reporting evidence that hillocks and their stem cells are physiologically distinct from other … Read more

The Cell: Fundamental Unit of Life

The cell, often described as the fundamental unit of life, represents the building block of all living organisms. This microscopic entity is the smallest structural and functional unit of life, capable of carrying out the essential processes necessary for an organism’s survival and reproduction. From single-celled organisms like bacteria to complex multicellular organisms like humans, … Read more

New study reveals striking similarities between ALS and FTLD at cellular level

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), seemingly distinct neurological disorders, have long puzzled doctors and scientists with their seemingly disparate symptoms and affected brain regions. However, a groundbreaking study published in Cell has unveiled remarkable similarities between these conditions at the cellular and molecular levels, shedding light on potential therapeutic targets that … Read more

Study links hereditary ALS to accumulation of non-functional ribosomal proteins

Amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, remains a formidable challenge in medical science. Characterized by the progressive degeneration of motor neurons, ALS robs individuals of their ability to control muscles, ultimately leading to paralysis and, tragically, death. Despite decades of research, the underlying causes of ALS remain elusive, and effective treatments remain elusive. … Read more

Study reveals how gene regulation shifts during cell differentiation

If you look at a nerve cell, a muscle cell, or a skin cell under the microscope, they appear strikingly different. However, every cell in our body has the same DNA and has descended from a common ancestor—the fertilized egg cell. The diversity we observe arises due to differentiation—a process during development where cells mature … Read more

Retinoic acid identified as key regulator of stem cell lineage plasticity in skin

When a child falls off her bike and scrapes her knee, skin stem cells rush to the rescue, growing new epidermis to cover the wound. But only some of the stem cells that will ultimately patch her up are normally dedicated to replenishing the epidermis that protects her body. Others are former hair follicle stem … Read more

Cryo-EM structures elucidate parental histone transfer during DNA replication

A research team has recently made a significant breakthrough in understanding how the DNA copying machine helps pass on epigenetic information to maintain gene traits at each cell division. Understanding how this coupled mechanism could lead to new treatments for cancer and other epigenetic diseases by targeting specific changes in gene activity. Their findings have recently been … Read more