Scientists discover molecule crucial for long-term memories

Whether it’s a first-time visit to a zoo or learning to ride a bicycle, childhood memories often stay with us well into adulthood. But what explains the persistence of these memories over a lifetime? A study published in Science Advances by an international team of researchers sheds light on this question, uncovering a biological mechanism … Read more

New nanomedicine therapy combines drug delivery and enhanced immunity for lung cancer

Researchers at Brigham and Women’s Hospital have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system’s ability to fight cancer. The team showed promising results for the new therapy in cancer cells in the lab and in mouse lung tumor models, with potential applications for improving … Read more

Hungarian research revives paradise fish as a model for behavioral genetics

Ethological research in Hungary is most often associated with studies on dogs, largely due to the extensive work conducted by researchers at ELTE Eötvös Loránd University. However, recent methodological advancements are shifting the focus towards a less conventional model: the paradise fish. These small, vibrant fish offer unique advantages, such as ease of handling and … Read more

Researchers discover mechanism disrupting cell signaling pathways

A group of researchers at University of California San Diego has identified the cause of a “short-circuit” in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases. The recent study, published in the journal Science Signaling, explores the biochemical mechanism that can interrupt the cellular communication chain—a … Read more

Study of skeletal remains reveals lives and deaths of knights templar successors in Spain

A research project led by the Universitat Rovira i Virgili (URV) and the Max Planck Institute has studied the remains of 25 individuals buried between the 12th and 15th centuries in the castle at Zorita de los Canes, Guadalajara. After exhuming the remains from the castle’s cemetery, the research team was able to determine the … Read more

Biomolecular analysis of fragmented bones sheds light on North American megafaunal extinction

50,000 years ago, North America was ruled by megafauna. Lumbering mammoths roamed the tundra, while forests were home to towering mastodons, fierce saber-toothed tigers and enormous wolves. Bison and extraordinarily tall camels moved in herds across the continent, while giant beavers plied its lakes and ponds. Immense ground sloths weighing over 1,000 kg were found … Read more

New research reveals loss of intestinal stem cells as early trigger for colorectal cancer

Research led by Weill Cornell Medicine has uncovered pivotal evidence suggesting that most colorectal cancers originate from the loss of intestinal stem cells prior to the onset of cancer-causing genetic mutations. This breakthrough, detailed in a study published on May 29 in Developmental Cell, challenges the longstanding theory of colorectal tumor initiation and opens new … Read more

Study links PI5P4K activity to hippo pathway regulation in cancer

Within the intricate landscape of cell membrane lipids and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have long dominated scientific research, particularly due to their roles in cancer, diabetes, and various cellular functions. However, the spotlight on PI3Ks has often overshadowed other crucial members of this lipid enzyme family, including phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks). … Read more

Study shows breakthrough infections enhance immune response to COVID-19

New research from scientists at La Jolla Institute for Immunology (LJI) suggests people who received COVID-19 vaccines and then experienced “breakthrough” infections are especially well armed against future SARS-CoV-2 infections. By analyzing blood samples from study volunteers, the LJI researchers discovered that people who experienced symptomatic breakthrough infections develop T cells that are better at … Read more

Scientists design drug-like molecules to block early stage influenza infection

Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists at Scripps Research and the Albert Einstein College of Medicine have designed drug-like molecules to do just that, by thwarting the first stage of influenza infection. … Read more

Scientists unravel how plants decide to grow or make oil

Proteins are molecular machines, with flexible pieces and moving parts. Understanding how these parts move helps scientists unravel the function a protein plays in living things—and potentially how to change its effects. Biochemists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory and colleagues at DOE’s Pacific Northwest National Laboratory (PNNL) have published a … Read more

Researchers discover new cell death pathway in response to DNA damage

Chemotherapy kills cancer cells. But the way these cells die appears to be different than previously understood. Researchers from the Netherlands Cancer Institute, led by Thijn Brummelkamp, have uncovered a completely new way in which cancer cells die: due to the Schlafen11 gene. “This is a very unexpected finding. Cancer patients have been treated with … Read more

Study suggests rethinking time steps in water simulations for improved accuracy

Computational scientists at the Department of Energy’s Oak Ridge National Laboratory have published a study in the Journal of Chemical Theory and Computation that questions a long-accepted factor in simulating the molecular dynamics of water: the 2-femtosecond (one quadrillionth of a second) time step. The femtosecond is a timescale used by scientists to measure the … Read more

Microbial Genetics: Genetic Mechanisms in Bacteria and Archaea

Microbial genetics is a specialized field within genetics that focuses on the study of genetic mechanisms in bacteria and archaea, collectively referred to as microorganisms or microbes. These single-celled organisms play crucial roles in various ecosystems, contributing to nutrient cycling, biogeochemical processes, symbiotic relationships, and human health. Microbial genetics explores the diversity, evolution, regulation, and … Read more

Systems Biology: Integrating Biological Processes into Complex Systems

Systems biology is an interdisciplinary field that seeks to understand biological systems as integrated networks of components, processes, and interactions, rather than isolated parts. It combines principles from biology, mathematics, computer science, engineering, and other disciplines to analyze complex biological phenomena at multiple scales, from molecular and cellular levels to tissues, organs, organisms, populations, and … Read more

Pharmacology: Study of Drug Action and Interaction with Organisms

Pharmacology is a multifaceted scientific discipline that delves into the study of drugs, their actions within biological systems, and their interactions with living organisms. It is a field that intersects with various branches of biology, chemistry, medicine, and pharmacy, aiming to understand how drugs work, their therapeutic effects, potential side effects, and mechanisms of action. … Read more

Comparative Anatomy: Comparing Anatomy Across Species

Comparative anatomy is a branch of biology that involves the study of anatomical structures and systems across different species to understand evolutionary relationships, adaptations, functional morphology, and biological diversity. By comparing the anatomy of organisms from various taxonomic groups, researchers can gain insights into evolutionary patterns, developmental processes, physiological functions, and ecological adaptations that have … Read more

Gene Editing Technologies: CRISPR and Beyond

Gene editing technologies have revolutionized the field of molecular biology and genetics by providing powerful tools to precisely modify DNA sequences, study gene functions, correct genetic mutations, and engineer biological systems. Among the most widely used and transformative gene editing technologies is CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and its associated protein, Cas (CRISPR-associated … Read more

Neurochemistry: Chemical Processes in the Nervous System

Neurochemistry is the branch of neuroscience that focuses on the chemical processes occurring within the nervous system, including the synthesis, release, reuptake, and metabolism of neurotransmitters, neuromodulators, and other signaling molecules. It encompasses the study of molecular mechanisms underlying neuronal communication, synaptic transmission, neuroplasticity, and brain function. Understanding neurochemistry is essential for unraveling the molecular … Read more

Developmental Biology: Processes from Fertilization to Organism Formation

Developmental biology is a fascinating field that explores the processes governing the growth, differentiation, and organization of cells into complex multicellular organisms. From the moment of fertilization, when a sperm cell fuses with an egg cell, to the formation of fully functional organs and tissues, developmental biology seeks to unravel the intricate molecular, cellular, and … Read more