Tumor growth

Study links PI5P4K activity to hippo pathway regulation in cancer

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Within the intricate landscape of cell membrane lipids and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have long dominated scientific research, particularly due to their roles in cancer, diabetes, and various cellular functions. However, the spotlight on PI3Ks has often overshadowed other crucial members of this lipid enzyme family, including phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks). … Read more

Genetics of Cancer: Causes and Treatments

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Cancer is a complex group of diseases characterized by uncontrolled cell growth and proliferation. It can affect virtually any part of the body and is caused by a combination of genetic, environmental, and lifestyle factors. The genetics of cancer play a crucial role in understanding its causes, development, progression, and potential treatments. Genetic Basis of … Read more

Sialidase-fused BiTE molecules enhance T-cell killing of solid tumors in mice

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Scientists from Scripps Research have enhanced an existing immunotherapy by removing the sugar coating surrounding solid tumors—such as in melanoma, breast, and prostate cancer—so T cells can more effectively kill tumor cells. They report in the journal Nature Biomedical Engineering that this tweak allows T cells to get closer to their targets, which dramatically improves T-cell killing of tumor … Read more

New molecule shows promise in targeting SCLC cells and boosting immunity

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A molecule has demonstrated its ability to kill tumor cells and incite an immune response in preclinical models of small cell lung cancer (SCLC), according to UT Southwestern Medical Center researchers. The findings, published in Nature Communications, could lead to more successful treatments for SCLC, one of the leading causes of cancer-related deaths in the … Read more

Scientists develop Zika-based therapy for brain cancer with reduced risk to healthy cells

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Scientists from Duke-NUS Medical School (Duke-NUS) have developed a new approach using the Zika virus to destroy brain cancer cells and inhibit tumor growth, while sparing healthy cells. Using Zika virus vaccine candidates developed at Duke-NUS, the team discovered how these strains target rapidly proliferating cells over mature cells—making them an ideal option to target … Read more

Retinoic acid identified as key regulator of stem cell lineage plasticity in skin

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When a child falls off her bike and scrapes her knee, skin stem cells rush to the rescue, growing new epidermis to cover the wound. But only some of the stem cells that will ultimately patch her up are normally dedicated to replenishing the epidermis that protects her body. Others are former hair follicle stem … Read more

Addition of ALK inhibitor shows promise in enhancing CAR-T cell therapy for neuroblastoma

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Chimeric antigen receptor (CAR)-T cell therapy is a potent emerging weapon against cancer, altering patients’ T cells so they can better find and destroy tumor cells. But CAR-T cell therapy doesn’t work well in every cancer—including many cases of neuroblastoma, a cancer that begins in young children’s nerve tissue and can metastasize to multiple areas … Read more

Study unveils how neutrophils support tumor growth

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A groundbreaking research endeavor led by the A*STAR.Singapore Immunology Network (A*STAR.SIgN) has uncovered a profound shift in the behavior of neutrophils, a vital component of the body’s immune system, within certain cancer contexts. Rather than combating malignancies, these neutrophils undergo a transformation that actively fosters tumor growth. Through meticulous examination of neutrophils as they infiltrate … Read more

Prosaposin protein could be key to enhancing cancer immunotherapy, study finds

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Successful immunotherapy for cancer involves activating a person’s own T cells to identify telltale proteins called antigens on the surface of a tumor and attack it. But some tumors have a trick: They hide themselves from the immune system by preventing their antigens from being displayed. A team led by Harvard Medical School researchers at … Read more