There’s a hot new BEC in town that has nothing to do with bacon, egg, and cheese. You won’t find it at your local bodega, but in the coldest place in New York: the lab of Columbia physicist Sebastian Will, whose experimental group specializes in pushing atoms and molecules to temperatures just fractions of a … Read more
Within the intricate landscape of cell membrane lipids and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have long dominated scientific research, particularly due to their roles in cancer, diabetes, and various cellular functions. However, the spotlight on PI3Ks has often overshadowed other crucial members of this lipid enzyme family, including phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks). … Read more
In organic chemistry, π-stacking systems are supramolecular structures that arise due to the dispersion force, a type of intermolecular noncovalent interaction. They are a common occurrence in nature. The stabilized structure of DNA is a very prominent example of a π-stacking system, and so are the arrangement of amino acids in certain proteins. Interestingly, π-stacking … Read more
Proteins are molecular machines, with flexible pieces and moving parts. Understanding how these parts move helps scientists unravel the function a protein plays in living things—and potentially how to change its effects. Biochemists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory and colleagues at DOE’s Pacific Northwest National Laboratory (PNNL) have published a … Read more
Systems biology is an interdisciplinary field that seeks to understand biological systems as integrated networks of components, processes, and interactions, rather than isolated parts. It combines principles from biology, mathematics, computer science, engineering, and other disciplines to analyze complex biological phenomena at multiple scales, from molecular and cellular levels to tissues, organs, organisms, populations, and … Read more
Developmental biology is a fascinating field that explores the processes governing the growth, differentiation, and organization of cells into complex multicellular organisms. From the moment of fertilization, when a sperm cell fuses with an egg cell, to the formation of fully functional organs and tissues, developmental biology seeks to unravel the intricate molecular, cellular, and … Read more
Molecular biology is a branch of biology that explores the structure, function, and interactions of biomolecules, such as DNA, RNA, proteins, lipids, and carbohydrates, at the molecular level. It encompasses a wide range of techniques, methodologies, and disciplines aimed at understanding biological processes, genetic information flow, gene expression, cellular functions, and molecular mechanisms underlying life. … Read more
Whispering-gallery-mode (WGM) resonators have long fascinated scientists and engineers with their ability to concentrate and manipulate light in minute circular paths, akin to the way whispering galleries focus sound waves. This unique property has led to their utilization in various sensing applications, from detecting chemical signatures to monitoring single molecules. However, their widespread adoption has … Read more
Cellular communication relies on receptor molecules on the cell surface. The periodic uptake and sorting of these receptors, critical for their degradation or recycling, are governed by an elaborate machinery prominently featuring the Commander complex. Research teams at the Institute of Biotechnology, University of Helsinki, led by Dr. Markku Varjosalo and Prof. Juha Huiskonen dissected … Read more
The periodic table is a tabular arrangement of chemical elements, organized by their atomic number, electron configuration, and recurring chemical properties. It provides a systematic way to categorize and understand the behavior of elements based on their shared characteristics. Dmitri Mendeleev is credited with developing the first periodic table in 1869, arranging elements by their … Read more
In a groundbreaking experiment reminiscent of stop-motion photography, scientists have achieved the remarkable feat of isolating the energetic movement of an electron while simultaneously “freezing” the motion of the much larger atom it orbits within a sample of liquid water. Published in the esteemed journal Science, the findings represent a significant leap forward in our … Read more
An interdisciplinary collaboration has used a cutting-edge form of RNA tagging to map the gene expression that occurs during follicle maturation and ovulation in mice. The resulting atlas reveals a slew of previously unknown cellular and molecular interactions that drive ovulation, which is crucial for female fertility. The findings could prove pivotal for developing therapeutic … Read more
Ribosomes stand as pivotal players in the intricate dance of cellular life, serving as the molecular machineries responsible for protein synthesis. This fundamental process is at the heart of cellular function, enabling the creation of the diverse array of proteins that carry out essential roles in living organisms. The role of ribosomes in protein synthesis … Read more
Chiral optical materials have garnered considerable interest across various disciplines due to their versatile applications in remote sensing, three-dimensional displays, information communication, and optical information storage. In response to the growing demand for stable and environmentally friendly materials, there is a keen anticipation surrounding two-dimensional, chiral, lead-free halide double perovskites, which are poised to exhibit … Read more
Immunology is the branch of biology that focuses on the study of the immune system, a complex and highly specialized network of cells, tissues, and organs that work together to defend the body against harmful pathogens, such as bacteria, viruses, fungi, and parasites. The immune system is a crucial component of the body’s defense mechanisms, … Read more
Physics, often referred to as the fundamental science, is a branch of natural science that seeks to understand the fundamental principles governing the behavior of matter and energy in the universe. It is a discipline that explores the properties of the smallest particles at the quantum level and the vastness of cosmic structures at the … Read more
Based on blood tests, it is possible to detect rare genetic diseases, recognize cancer, or determine the inflammation level in the body. Moreover, due to the rapid development of medical diagnostics based on biofluid analysis, many efforts are being made worldwide to adapt medical approaches, making personalized medicine the paradigm of future health care. Moving … Read more
Exciting developments in high-resolution fluorescence microscopy offer researchers a breakthrough – the availability of biocompatible molecular rulers designed for calibrating the latest super-resolution microscopy methods. Super-resolution microscopy techniques have recently achieved optical resolutions in the nanometer range, corresponding to the size of cellular molecules. However, assessing the achieved resolution on cellular structures like multiprotein complexes … Read more
A significant breakthrough in the pursuit of direct air capture (DAC) of carbon dioxide has been achieved by scientists at the Department of Energy’s Oak Ridge National Laboratory. Published in Cell Reports Physical Science, the research delves into the foundational aspects of carbon dioxide sequestration using aqueous glycine, an absorbent amino acid. The goal of … Read more
An international team of scientists has uncovered the vital role of microglia, the immune cells in the brain that acts as its dedicated defense team, in early human brain development. By incorporating microglia into lab-grown brain organoids, scientists were able mimic the complex environment within the developing human brain to understand how microglia influence brain … Read more