Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists at Scripps Research and the Albert Einstein College of Medicine have designed drug-like molecules to do just that, by thwarting the first stage of influenza infection. … Read more
Proteins are molecular machines, with flexible pieces and moving parts. Understanding how these parts move helps scientists unravel the function a protein plays in living things—and potentially how to change its effects. Biochemists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory and colleagues at DOE’s Pacific Northwest National Laboratory (PNNL) have published a … Read more
Cancer is a complex group of diseases characterized by uncontrolled cell growth and proliferation. It can affect virtually any part of the body and is caused by a combination of genetic, environmental, and lifestyle factors. The genetics of cancer play a crucial role in understanding its causes, development, progression, and potential treatments. Genetic Basis of … Read more
Biotechnology is a rapidly evolving field that harnesses biological processes and systems to develop innovative solutions for various applications in medicine and industry. It encompasses a diverse range of techniques, including genetic engineering, fermentation, and cell culture, to manipulate biological systems for practical purposes. Biotechnology has revolutionized healthcare, agriculture, environmental science, and industrial manufacturing, offering … Read more
Research appearing in the Journal of Medicinal Chemistry shows for the first time SARS-CoV-2, the virus responsible for COVID-19, can be inhibited from replicating in living cell cultures using a compound that targets “Mac-1,” a protein key to defending SARS-CoV-2 against the human immune response. University of Kansas researchers in the lab of Anthony Fehr, associate professor … Read more
Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt’s state-of-the-art instrumentation in the Center for Structural Biology’s Cryo-Electron Microscopy Facility, Eichman, Chazin, and their colleagues provided detailed visualizations of a multi-functional protein in action, which sheds light … Read more
Helicases are enzymes that unwind DNA and RNA. They’re central to cellular life, implicated in a number of cancers and infections—and, alas, extraordinarily difficult to target with drugs. Now, new research provides a powerful platform for designing covalent inhibitors tailored to target helicases. The paper, published in the Journal of the American Chemical Society, describes how researchers used … Read more
When a child falls off her bike and scrapes her knee, skin stem cells rush to the rescue, growing new epidermis to cover the wound. But only some of the stem cells that will ultimately patch her up are normally dedicated to replenishing the epidermis that protects her body. Others are former hair follicle stem … Read more
Boston College researchers used a mild charge of electricity to precisely modify proteins, a new tool that can be used to develop novel biotherapeutics and protein-based research tools, the team reported recently in the journal Nature Chemistry. The team, led by BC professors of chemistry Abhishek Chatterjee and Eranthie Weerapana, developed and optimized a novel … Read more
Nearly 30 years ago, scientists discovered a unique class of anticancer molecules in a family of bryozoans, a phylum of marine invertebrates found in tropical waters. The chemical structures of these molecules, which consist of a dense, highly complex knot of oxidized rings and nitrogen atoms, has attracted the interest of organic chemists worldwide, who … Read more