High-throughput screening

Biochemistry: Chemical Processes in Living Organisms

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Biochemistry is the branch of science that explores the chemical processes and molecules within living organisms. It delves into the structure, function, and interactions of biomolecules such as proteins, nucleic acids, carbohydrates, lipids, and metabolites, elucidating fundamental principles of life, cellular functions, biochemical pathways, and molecular mechanisms underlying biological processes. Proteins Proteins are essential biomolecules … Read more

Mac-1 inhibitor compound shows promise in blocking SARS-CoV-2 replication in cell cultures

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Research appearing in the Journal of Medicinal Chemistry shows for the first time SARS-CoV-2, the virus responsible for COVID-19, can be inhibited from replicating in living cell cultures using a compound that targets “Mac-1,” a protein key to defending SARS-CoV-2 against the human immune response. University of Kansas researchers in the lab of Anthony Fehr, associate professor … Read more

Covalent inhibitor platform designed for targeting helicases in cancers and viral infections

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Helicases are enzymes that unwind DNA and RNA. They’re central to cellular life, implicated in a number of cancers and infections—and, alas, extraordinarily difficult to target with drugs. Now, new research provides a powerful platform for designing covalent inhibitors tailored to target helicases. The paper, published in the Journal of the American Chemical Society, describes how researchers used … Read more