A recent study led by USC Stem Cell scientist Janos Peti-Peterdi reveals that a loss of salt and body fluid can stimulate kidney regeneration and repair in mice. This groundbreaking research, published in the Journal of Clinical Investigation, uncovers an innate regenerative response driven by a small population of kidney cells known as the macula … Read more
Researchers at Brigham and Women’s Hospital have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system’s ability to fight cancer. The team showed promising results for the new therapy in cancer cells in the lab and in mouse lung tumor models, with potential applications for improving … Read more
A group of researchers at University of California San Diego has identified the cause of a “short-circuit” in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases. The recent study, published in the journal Science Signaling, explores the biochemical mechanism that can interrupt the cellular communication chain—a … Read more
Researchers at Vanderbilt University Medical Center (VUMC) have made a significant breakthrough by isolating human monoclonal antibodies against influenza B. This virus is a notable public health threat, particularly affecting children, the elderly, and individuals with weakened immune systems. While seasonal flu vaccines provide coverage against both influenza A and B, they do not always … Read more
Scientists have discovered that the most widely-used class of antifungals in the world causes pathogens to self-destruct. The University of Exeter-led research could help improve ways to protect food security and human lives. Fungal diseases account for the loss of up to a quarter of the world’s crops. They also pose a risk to humans … Read more
Within the intricate landscape of cell membrane lipids and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have long dominated scientific research, particularly due to their roles in cancer, diabetes, and various cellular functions. However, the spotlight on PI3Ks has often overshadowed other crucial members of this lipid enzyme family, including phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks). … Read more
Our brains are made of tens of billions of nerve cells called neurons. These cells communicate with each other through biomolecules called neurotransmitters. Serotonin, a type of neurotransmitter, is produced by serotonin neurons in our brains and influences many of our behavioral and cognitive functions such as memory, sleep, and mood. Using mice, scientists at … Read more
In a significant advancement for drug research and chemical synthesis, a team of chemists at the University of Münster has devised a new method to precisely integrate the biologically significant difluoromethyl group into pyridines at specific sites. The difluoromethyl group, composed of carbon, two fluorine atoms, and a hydrogen atom, is crucial for determining the … Read more
Pharmacology is a multifaceted scientific discipline that delves into the study of drugs, their actions within biological systems, and their interactions with living organisms. It is a field that intersects with various branches of biology, chemistry, medicine, and pharmacy, aiming to understand how drugs work, their therapeutic effects, potential side effects, and mechanisms of action. … Read more
Neurochemistry is the branch of neuroscience that focuses on the chemical processes occurring within the nervous system, including the synthesis, release, reuptake, and metabolism of neurotransmitters, neuromodulators, and other signaling molecules. It encompasses the study of molecular mechanisms underlying neuronal communication, synaptic transmission, neuroplasticity, and brain function. Understanding neurochemistry is essential for unraveling the molecular … Read more
Cancer is a complex group of diseases characterized by uncontrolled cell growth and proliferation. It can affect virtually any part of the body and is caused by a combination of genetic, environmental, and lifestyle factors. The genetics of cancer play a crucial role in understanding its causes, development, progression, and potential treatments. Genetic Basis of … Read more
Endocrinology is the branch of biology and medicine that deals with the study of hormones and the endocrine system. Hormones are chemical messengers produced by glands in the endocrine system, which regulate various physiological processes and maintain homeostasis in the body. The endocrine system consists of glands and organs that secrete hormones directly into the … Read more
Scientists from Scripps Research have enhanced an existing immunotherapy by removing the sugar coating surrounding solid tumors—such as in melanoma, breast, and prostate cancer—so T cells can more effectively kill tumor cells. They report in the journal Nature Biomedical Engineering that this tweak allows T cells to get closer to their targets, which dramatically improves T-cell killing of tumor … Read more
Nonsense-mediated RNA decay, or NMD, is an evolutionarily conserved molecular mechanism in which potentially defective messenger RNAs, or mRNAs (genetic material that instructs the body on how to make proteins), are degraded. Disruption of the NMD pathway can lead to neurological disorders, immune diseases, cancers, and other pathologies. Mutations in human NMD regulators are seen … Read more
Virology is the scientific study of viruses, their structure, function, evolution, and interactions with host organisms. Viruses are microscopic infectious agents that can infect a wide range of living organisms, from bacteria and archaea to plants, animals, and humans. They are unique entities that straddle the boundary between living and non-living, as they require host … Read more
Cellular respiration is a fundamental biological process that occurs in living cells to generate energy in the form of adenosine triphosphate (ATP). This process involves the breakdown of organic molecules, such as glucose, through a series of biochemical reactions that release energy stored in chemical bonds. Cellular respiration is essential for the survival and functioning … Read more
Neurobiology is a fascinating field of study that delves into the intricacies of the nervous system, which serves as the body’s communication and control center. The nervous system is a complex network of cells, tissues, and organs that coordinate sensory perception, motor function, cognition, and behavior. In this exploration of neurobiology, we will delve into … Read more
Immunology is the branch of biomedical science that focuses on the study of the immune system, which is the body’s intricate network of organs, tissues, cells, and molecules that work together to defend against pathogens, foreign substances, and abnormal cells. The immune system plays a vital role in maintaining health and protecting the body from … Read more
Biotechnology is a rapidly evolving field that harnesses biological processes and systems to develop innovative solutions for various applications in medicine and industry. It encompasses a diverse range of techniques, including genetic engineering, fermentation, and cell culture, to manipulate biological systems for practical purposes. Biotechnology has revolutionized healthcare, agriculture, environmental science, and industrial manufacturing, offering … Read more
Physiology is the branch of biology that focuses on the study of the functions and processes of living organisms and their parts. It encompasses various levels of organization, from cells and tissues to organs and organ systems, and examines how these components work together to maintain homeostasis and support life. In this discussion, we’ll delve … Read more