New nanomedicine therapy combines drug delivery and enhanced immunity for lung cancer

Researchers at Brigham and Women’s Hospital have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system’s ability to fight cancer. The team showed promising results for the new therapy in cancer cells in the lab and in mouse lung tumor models, with potential applications for improving … Read more

Study links PI5P4K activity to hippo pathway regulation in cancer

Within the intricate landscape of cell membrane lipids and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have long dominated scientific research, particularly due to their roles in cancer, diabetes, and various cellular functions. However, the spotlight on PI3Ks has often overshadowed other crucial members of this lipid enzyme family, including phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks). … Read more

How viruses could become the next cancer treatment

In the global quest for effective cancer treatments, researchers are uncovering promising strategies in the most unexpected of places: the very viruses we typically strive to avoid. Pathogens such as the common cold and influenza, once seen solely as threats to our health, are now being studied for their potential to target and destroy cancer … Read more

Researchers discover new cell death pathway in response to DNA damage

Chemotherapy kills cancer cells. But the way these cells die appears to be different than previously understood. Researchers from the Netherlands Cancer Institute, led by Thijn Brummelkamp, have uncovered a completely new way in which cancer cells die: due to the Schlafen11 gene. “This is a very unexpected finding. Cancer patients have been treated with … Read more

Immunotherapy: Harnessing the Immune System for Disease Treatment

Immunotherapy represents a revolutionary approach to disease treatment that harnesses the power of the immune system to combat various ailments, including cancer, autoimmune disorders, infectious diseases, and allergies. Unlike traditional treatments such as chemotherapy or surgery, which directly target the disease, immunotherapy works by stimulating or enhancing the body’s immune response to recognize and destroy … Read more

Genetics of Cancer: Causes and Treatments

Cancer is a complex group of diseases characterized by uncontrolled cell growth and proliferation. It can affect virtually any part of the body and is caused by a combination of genetic, environmental, and lifestyle factors. The genetics of cancer play a crucial role in understanding its causes, development, progression, and potential treatments. Genetic Basis of … Read more

Animal Physiology: Functions and Adaptations in Animals

Animal physiology is the branch of biology that focuses on understanding the biological functions and adaptations of animals, ranging from microscopic organisms to complex multicellular organisms. It encompasses a wide range of topics, including cellular processes, organ systems, homeostasis, metabolism, reproduction, behavior, and adaptations to diverse environments. By studying animal physiology, scientists gain insights into … Read more

Cellular Respiration: Energy Production in Cells

Cellular respiration is a fundamental biological process that occurs in living cells to generate energy in the form of adenosine triphosphate (ATP). This process involves the breakdown of organic molecules, such as glucose, through a series of biochemical reactions that release energy stored in chemical bonds. Cellular respiration is essential for the survival and functioning … Read more

Immunology: The Body’s Defense Mechanisms

Immunology is the branch of biomedical science that focuses on the study of the immune system, which is the body’s intricate network of organs, tissues, cells, and molecules that work together to defend against pathogens, foreign substances, and abnormal cells. The immune system plays a vital role in maintaining health and protecting the body from … Read more

Study links fatty acid binding protein 5 (FABP5) to obesity-driven liver cancer

Metabolic diseases like obesity can increase the risk of developing liver cancer, research has shown. But how one disease predisposes to the other is unclear. In a new study, Yale researchers uncovered a key role played by a molecule called fatty acid binding protein 5 (FABP5) and found that inhibiting it blocked tumor progression in … Read more

New 3D imaging technique identifies genes controlling melanoma cell shape changes

Cancer cells can change shape to travel around the body and spread (metastasize), but how they know when to do this has remained elusive. Researchers have now used a new technique to identify two genes that control how melanoma skin cancer cells change shape in response to their environment—offering two potential drug targets to stop … Read more

New technique revives decades-old cancer samples for immune response studies

Scientists have developed an improved technique for reading the genetic material associated with the body’s immune response to cancer, making it possible to study tissue samples that have been stored in archives for decades. Using this technique, which is much more sensitive than commercial equivalents and less costly, researchers are able to analyze archival cancer … Read more

New molecule shows promise in targeting SCLC cells and boosting immunity

A molecule has demonstrated its ability to kill tumor cells and incite an immune response in preclinical models of small cell lung cancer (SCLC), according to UT Southwestern Medical Center researchers. The findings, published in Nature Communications, could lead to more successful treatments for SCLC, one of the leading causes of cancer-related deaths in the … Read more

Scientists develop Zika-based therapy for brain cancer with reduced risk to healthy cells

Scientists from Duke-NUS Medical School (Duke-NUS) have developed a new approach using the Zika virus to destroy brain cancer cells and inhibit tumor growth, while sparing healthy cells. Using Zika virus vaccine candidates developed at Duke-NUS, the team discovered how these strains target rapidly proliferating cells over mature cells—making them an ideal option to target … Read more

Researchers develop novel technique for precise protein modification using electricity

Boston College researchers used a mild charge of electricity to precisely modify proteins, a new tool that can be used to develop novel biotherapeutics and protein-based research tools, the team reported recently in the journal Nature Chemistry. The team, led by BC professors of chemistry Abhishek Chatterjee and Eranthie Weerapana, developed and optimized a novel … Read more

KSHV manipulates host cell metabolism to drive cancer development

Cleveland Clinic researchers have discovered a key mechanism used by Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), to induce cancer. The research points to effective new treatment options for KSHV-associated cancers, including Kaposi’s sarcoma, primary effusion lymphoma, and HHV8-associated multicentric Castleman disease. “Our findings have significant implications: viruses cause between 10% … Read more

New study reveals mucus role in pancreatic cancer transformation

Knowing exactly what’s inside a tumor can maximize our ability to fight cancer. But that knowledge doesn’t come easy. Tumors are clusters of constantly changing cancer cells. Some become common cancer variants. Others morph into deadlier, drug-resistant varieties. No one truly understands what governs this chaotic behavior. Now, Cold Spring Harbor Laboratory (CSHL) Professor David … Read more

140-Gene signature correlates with enhanced disease-free survival in NSCLC patients treated with durvalumab and low-dose radiation

A groundbreaking study has recently identified a cluster of 140 genes that may serve as a predictive tool for improved disease-free survival among patients grappling with non-small cell lung cancer (NSCLC) undergoing a combined treatment of immunotherapy and low-dose radiation. Published  in Cell Reports Medicine, the findings propose that this distinctive “gene signature” could delineate … Read more

Chronic stress triggers neutrophil webs, boosting cancer spread, study finds

Stress is inevitable. But too much of it can be terrible for our health. Chronic stress can increase our risk for heart disease and strokes. It may also help cancer spread. How this works has remained a mystery—a challenge for cancer care. Xue-Yan He, a former postdoc in Cold Spring Harbor Laboratory (CSHL) Adjunct Professor … Read more

Immune gene variation linked to lung cancer risk, especially in smokers

Recent strides in cancer research have underscored the critical involvement of the immune system, particularly in the remarkable achievements of cancer immunotherapy. A groundbreaking investigation spearheaded by scientists at the Icahn School of Medicine at Mount Sinai in New York, in collaboration with the University of Helsinki and Massachusetts General Hospital, has shed illuminating insights … Read more