Researchers at Brigham and Women’s Hospital have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system’s ability to fight cancer. The team showed promising results for the new therapy in cancer cells in the lab and in mouse lung tumor models, with potential applications for improving … Read more
Research led by Weill Cornell Medicine has uncovered pivotal evidence suggesting that most colorectal cancers originate from the loss of intestinal stem cells prior to the onset of cancer-causing genetic mutations. This breakthrough, detailed in a study published on May 29 in Developmental Cell, challenges the longstanding theory of colorectal tumor initiation and opens new … Read more
Within the intricate landscape of cell membrane lipids and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have long dominated scientific research, particularly due to their roles in cancer, diabetes, and various cellular functions. However, the spotlight on PI3Ks has often overshadowed other crucial members of this lipid enzyme family, including phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks). … Read more
Chemotherapy kills cancer cells. But the way these cells die appears to be different than previously understood. Researchers from the Netherlands Cancer Institute, led by Thijn Brummelkamp, have uncovered a completely new way in which cancer cells die: due to the Schlafen11 gene. “This is a very unexpected finding. Cancer patients have been treated with … Read more
Immunotherapy represents a revolutionary approach to disease treatment that harnesses the power of the immune system to combat various ailments, including cancer, autoimmune disorders, infectious diseases, and allergies. Unlike traditional treatments such as chemotherapy or surgery, which directly target the disease, immunotherapy works by stimulating or enhancing the body’s immune response to recognize and destroy … Read more
Cancer is a complex group of diseases characterized by uncontrolled cell growth and proliferation. It can affect virtually any part of the body and is caused by a combination of genetic, environmental, and lifestyle factors. The genetics of cancer play a crucial role in understanding its causes, development, progression, and potential treatments. Genetic Basis of … Read more
Endocrinology is the branch of biology and medicine that deals with the study of hormones and the endocrine system. Hormones are chemical messengers produced by glands in the endocrine system, which regulate various physiological processes and maintain homeostasis in the body. The endocrine system consists of glands and organs that secrete hormones directly into the … Read more
Hvidovre Hospital has the world’s first prototype of a sensor capable of detecting errors in MRI scans using laser light and gas. The new sensor, developed by a young researcher at the University of Copenhagen and Hvidovre Hospital, can thereby do what is impossible for current electrical sensors—and hopefully pave the way for MRI scans … Read more
Scientists from Scripps Research have enhanced an existing immunotherapy by removing the sugar coating surrounding solid tumors—such as in melanoma, breast, and prostate cancer—so T cells can more effectively kill tumor cells. They report in the journal Nature Biomedical Engineering that this tweak allows T cells to get closer to their targets, which dramatically improves T-cell killing of tumor … Read more
Neurobiology is a fascinating field of study that delves into the intricacies of the nervous system, which serves as the body’s communication and control center. The nervous system is a complex network of cells, tissues, and organs that coordinate sensory perception, motor function, cognition, and behavior. In this exploration of neurobiology, we will delve into … Read more
Immunology is the branch of biomedical science that focuses on the study of the immune system, which is the body’s intricate network of organs, tissues, cells, and molecules that work together to defend against pathogens, foreign substances, and abnormal cells. The immune system plays a vital role in maintaining health and protecting the body from … Read more
Metabolic diseases like obesity can increase the risk of developing liver cancer, research has shown. But how one disease predisposes to the other is unclear. In a new study, Yale researchers uncovered a key role played by a molecule called fatty acid binding protein 5 (FABP5) and found that inhibiting it blocked tumor progression in … Read more
A molecule has demonstrated its ability to kill tumor cells and incite an immune response in preclinical models of small cell lung cancer (SCLC), according to UT Southwestern Medical Center researchers. The findings, published in Nature Communications, could lead to more successful treatments for SCLC, one of the leading causes of cancer-related deaths in the … Read more
Cleveland Clinic researchers have discovered a key mechanism used by Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), to induce cancer. The research points to effective new treatment options for KSHV-associated cancers, including Kaposi’s sarcoma, primary effusion lymphoma, and HHV8-associated multicentric Castleman disease. “Our findings have significant implications: viruses cause between 10% … Read more
Knowing exactly what’s inside a tumor can maximize our ability to fight cancer. But that knowledge doesn’t come easy. Tumors are clusters of constantly changing cancer cells. Some become common cancer variants. Others morph into deadlier, drug-resistant varieties. No one truly understands what governs this chaotic behavior. Now, Cold Spring Harbor Laboratory (CSHL) Professor David … Read more
A groundbreaking research endeavor led by the A*STAR.Singapore Immunology Network (A*STAR.SIgN) has uncovered a profound shift in the behavior of neutrophils, a vital component of the body’s immune system, within certain cancer contexts. Rather than combating malignancies, these neutrophils undergo a transformation that actively fosters tumor growth. Through meticulous examination of neutrophils as they infiltrate … Read more
A groundbreaking study has recently identified a cluster of 140 genes that may serve as a predictive tool for improved disease-free survival among patients grappling with non-small cell lung cancer (NSCLC) undergoing a combined treatment of immunotherapy and low-dose radiation. Published in Cell Reports Medicine, the findings propose that this distinctive “gene signature” could delineate … Read more
Successful immunotherapy for cancer involves activating a person’s own T cells to identify telltale proteins called antigens on the surface of a tumor and attack it. But some tumors have a trick: They hide themselves from the immune system by preventing their antigens from being displayed. A team led by Harvard Medical School researchers at … Read more
Stress is inevitable. But too much of it can be terrible for our health. Chronic stress can increase our risk for heart disease and strokes. It may also help cancer spread. How this works has remained a mystery—a challenge for cancer care. Xue-Yan He, a former postdoc in Cold Spring Harbor Laboratory (CSHL) Adjunct Professor … Read more