Early memory complaints may signal preclinical Alzheimer’s disease, new study finds

A groundbreaking study underscores the importance of addressing concerns about persistent memory loss with a healthcare provider. Conducted by researchers from Mass General Brigham, the study reveals that reports of cognitive decline by patients and their close family members or study partners may indicate early changes in the brain associated with Alzheimer’s disease. This discovery … Read more

Neurobiology: Exploring the Nervous System

Neurobiology is a fascinating field of study that delves into the intricacies of the nervous system, which serves as the body’s communication and control center. The nervous system is a complex network of cells, tissues, and organs that coordinate sensory perception, motor function, cognition, and behavior. In this exploration of neurobiology, we will delve into … Read more

Software predicts protein co-aggregation in amyloid fibrils with over 94% accuracy

Scientists from St Petersburg University and the University of Montpellier have developed the first software enabling the prediction of pairs of proteins in amyloid fibrils capable of co-aggregation, i.e. a process by which proteins become attached to one another. Their studies have shown an accuracy of more than 94%. The work is published in the Journal of Molecular … Read more

Study finds disrupted amyloid production, not plaques, may trigger Alzheimer’s

A University of Kansas study of rare gene mutations that cause hereditary Alzheimer’s disease shows these mutations disrupt the production of a small sticky protein called amyloid. Plaques composed of amyloid are notoriously found in the brain in Alzheimer’s disease and have long been considered responsible for the inexorable loss of neurons and cognitive decline. … Read more

Light and sound at 40 Hz may reduce Alzheimer’s by clearing brain waste

Emerging research, both at prestigious institutions like MIT and elsewhere, underscores the potential of harnessing gamma brain rhythm frequencies to combat Alzheimer’s disease (AD). Studies reveal promising findings indicating that light flickering and sound clicking at the 40 Hz gamma frequency can not only slow down the progression of AD but also alleviate symptoms in … Read more

New insights into protein misfolding could lead to better treatments for glaucoma and beyond

From Parkinson’s and Alzheimer’s to cardiac arrhythmia, amyloids are linked to a number of diseases. These aggregates of proteins form in the body when a protein loses its normal structure and misfolds or mutates. And since many of these proteins are large and complicated, just how some of these mutations occur and aggregate remains a … Read more

New drug delivery platform utilizes helical amyloid fibers for targeted release

Researchers at the University of North Carolina at Chapel Hill have pioneered a novel drug delivery system centered on helical amyloid fibers engineered to release medications upon reaching body temperatures. Their recent study, published in Nature Communications on January 26, delves into the intricate structural intricacies underlying diseases like Alzheimer’s, potentially unlocking a mechanism to … Read more