New drugs

Study links PI5P4K activity to hippo pathway regulation in cancer

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Within the intricate landscape of cell membrane lipids and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have long dominated scientific research, particularly due to their roles in cancer, diabetes, and various cellular functions. However, the spotlight on PI3Ks has often overshadowed other crucial members of this lipid enzyme family, including phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks). … Read more

Chemists develop method for site-selective difluoromethylation of pyridines

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In a significant advancement for drug research and chemical synthesis, a team of chemists at the University of Münster has devised a new method to precisely integrate the biologically significant difluoromethyl group into pyridines at specific sites. The difluoromethyl group, composed of carbon, two fluorine atoms, and a hydrogen atom, is crucial for determining the … Read more

Pharmacology: Study of Drug Action and Interaction with Organisms

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Pharmacology is a multifaceted scientific discipline that delves into the study of drugs, their actions within biological systems, and their interactions with living organisms. It is a field that intersects with various branches of biology, chemistry, medicine, and pharmacy, aiming to understand how drugs work, their therapeutic effects, potential side effects, and mechanisms of action. … Read more

New 3D imaging technique identifies genes controlling melanoma cell shape changes

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Cancer cells can change shape to travel around the body and spread (metastasize), but how they know when to do this has remained elusive. Researchers have now used a new technique to identify two genes that control how melanoma skin cancer cells change shape in response to their environment—offering two potential drug targets to stop … Read more

Periodic Table

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The periodic table is a tabular arrangement of chemical elements, organized by their atomic number, electron configuration, and recurring chemical properties. It provides a systematic way to categorize and understand the behavior of elements based on their shared characteristics. Dmitri Mendeleev is credited with developing the first periodic table in 1869, arranging elements by their … Read more

New study suggests potential to shorten treatment duration for drug-resistant TB

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Patients who have drug-resistant tuberculosis (TB) have a similar microbiological response to bedaquiline-based second-line medications as patients with drug-sensitive TB taking first-line regimens, according to researchers at Weill Cornell Medicine in New York and GHESKIO Centers in Haiti. Second-line medications are those that are given when one or more of the drugs given first for … Read more