Scientists create opioid with reduced overdose potential

Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose. In a study appearing in ACS Central Science, researchers have identified a strategy to design safer opioids. They showed that an experimental opioid, which binds to an unconventional … Read more

Scientists recreate ancient ocean floor to study life’s origins

Where did life first form on Earth? Some scientists think it could have been around hydrothermal vents that may have existed at the bottom of the ocean 4.5 billion years ago. In a new paper in the journal Astrobiology, scientists at NASA’s Jet Propulsion Laboratory describe how they mimicked possible ancient undersea environments with a … Read more

Vitamin B6 breakdown inhibitor shows promise for vrain disorders

A low vitamin B6 level has negative effects on brain performance. A research team from Würzburg University Medicine has now found a way to delay the degradation of the vitamin. Vitamin B6 is important for brain metabolism. Accordingly, in various mental illnesses, a low vitamin B6 level is associated with impaired memory and learning abilities, … Read more

Study links mediodorsal thalamus activity to paranoia in humans and monkeys

The ability to adapt one’s beliefs about actions and their consequences in a constantly changing environment is a hallmark of advanced cognition. Disruptions to this ability can negatively impact cognition and behavior, potentially leading to states of mind such as paranoia, where there is a belief that others intend to cause harm. In a groundbreaking … Read more

Earliest evidence of managed cattle herding found in Northern Europe

Archaeologists have discovered evidence for the earliest cattle herds in northern Europe, at the site of Swifterbant in the Netherlands. Using a combination of zoological, botanical, and biochemical methods, they investigated the emergence of farming in northern Europe and found that, not only are these the earliest known domestic cattle, they were also managed in … Read more

Puddle frog study reveals how climate change threatens genetically uniform species

Scientists have studied puddle frogs to identify genetic variation hotspots and places where the climate crisis could wipe out populations too homogenous to adapt. Even widespread species could be genomically vulnerable to the climate crisis, scientists warn. By studying the DNA of puddle frogs living in central African rainforests, the scientists found that areas of … Read more

Ancient hunters shifted to specialized tools as elephants disappeared

A new study from Tel Aviv University identified the earliest appearance worldwide of special stone tools, used 400,000 years ago to process fallow deer. The tools, called Quina scrapers (after the site in France where they were first discovered), were unearthed at the prehistoric sites of Jaljulia and Qesem Cave. They are characterized by a … Read more

Worm activity may have sparked explosion of life on earth

One of Earth’s most consequential bursts of biodiversity—a 30-million-year period of explosive evolutionary changes spawning innumerable new species—may have the most modest of creatures to thank for the vital stage in life’s history: worms. The digging and burrowing of prehistoric worms and other invertebrates along ocean bottoms sparked a chain of events that released oxygen … Read more

Biomolecular analysis of fragmented bones sheds light on North American megafaunal extinction

50,000 years ago, North America was ruled by megafauna. Lumbering mammoths roamed the tundra, while forests were home to towering mastodons, fierce saber-toothed tigers and enormous wolves. Bison and extraordinarily tall camels moved in herds across the continent, while giant beavers plied its lakes and ponds. Immense ground sloths weighing over 1,000 kg were found … Read more

Parallel evolution of nectaries in ferns and flowering plants

Plants and the animals that eat them have evolved together in fascinating ways, creating a dynamic interplay of survival strategies. Many plants have developed physical and chemical defenses to fend off herbivores. A well-known strategy in flowering plants is to produce nectar to attract “ant bodyguards.” Recent research explores the evolution of this same defense … Read more

New research challenges long-held belief about primate brain evolution

Primates, including humans, have notably larger brains compared to most other mammals. For decades, scientists have speculated that diet, particularly the consumption of fruit, played a crucial role in the evolution of these larger brains. A groundbreaking study from the Max Planck Institute of Animal Behavior and the Smithsonian Tropical Research Institute now suggests that … Read more

Study links skeletal freedom in small birds to diverse flight styles

Small birds exhibit a remarkable range of flight styles, from the hovering maneuvers of hummingbirds to the bounding flight of sparrows and the soaring patterns of swifts and swallows. A recent study conducted by Cornell University researchers provides new insights into why these variations occur, suggesting that the structural evolution of wing bones in smaller … Read more

How brain activation affects behavior

Our brains are made of tens of billions of nerve cells called neurons. These cells communicate with each other through biomolecules called neurotransmitters. Serotonin, a type of neurotransmitter, is produced by serotonin neurons in our brains and influences many of our behavioral and cognitive functions such as memory, sleep, and mood. Using mice, scientists at … Read more

Heatmaps reveal different trematode species favor specific body locations in amphibian hosts

Trematodes, also known as flukes, are a class of parasitic flatworms with intricate lifecycles. This makes them interesting to scientists, but they are also significant to both human health and wildlife conservation. Trematodes can cause infection in humans when people eat food the flatworms have contaminated, including raw fish, crustaceans and vegetables. Though this is … Read more

12,000-year-old campsite in Chile reveals evidence of elephant hunting by early humans

Thousands of years ago, early hunter-gatherers returned regularly to Tagua Tagua Lake in Chile to hunt ancient elephants and take advantage of other local resources, according to a study published May 22 in the open-access journal PLOS ONE by Rafael Labarca of the Pontifical Catholic University of Chile and colleagues. Multiple archaeological sites are known … Read more

Study links gut microbiota composition to increased sensitivity towards fairness

Decision-making in social contexts is typically explained through psychological, social, and political lenses. However, groundbreaking research by Hilke Plassmann and her team from the Paris Brain Institute and the University of Bonn suggests that our gut microbiota might also play a crucial role. Their findings, published in the journal PNAS Nexus, reveal that changes in … Read more

How small mammal personalities influence forest regeneration

Scattered across the Penobscot Experimental Forest are veritable treasure troves for its denizens, each containing riches beyond comprehension. These caches do not contain gold or jewels—they’re filled with eastern white pine seeds and were placed by a team of researchers at the University of Maine for one purpose: to catch furry thieves red-handed. Brigit Humphreys, … Read more

Tiger beetles use ultrasound to mimic noxious moths, study finds

Bats, as the main predator of night-flying insects, create a selective pressure that has led many of their prey to evolve an early warning system of sorts: ears uniquely tuned to high-frequency bat echolocation. To date, scientists have found at least six orders of insects—including moths, beetles, crickets and grasshoppers—that have evolved ears capable of … Read more

Study shows decline in plant-pathogen interactions following loss of large herbivores in rainforest

Insects and microorganisms that feed on plants, cut up leaves, modify leaf tissue or produce leaf spots and other kinds of damage, are usually known as pests and considered harmful, yet interactions between plants and their natural enemies are important sources of biodiversity. In tropical forests, for example, these “pests” are part of large ecological … Read more

Animal Development: Embryonic Development and Morphogenesis

Animal development, also known as embryonic development, encompasses the complex processes through which a single fertilized egg cell transforms into a multicellular organism with distinct tissues, organs, and body structures. This intricate journey involves cellular differentiation, tissue organization, morphogenetic movements, and regulatory mechanisms that orchestrate the formation of body axes, germ layers, organ systems, and … Read more